All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study.
Identifieur interne : 003C23 ( Main/Exploration ); précédent : 003C22; suivant : 003C24All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study.
Auteurs : Michael Manns [Allemagne] ; Stanislas Pol [France] ; Ira M. Jacobson [États-Unis] ; Patrick Marcellin [France] ; Stuart C. Gordon [États-Unis] ; Cheng-Yuan Peng [Taïwan] ; Ting-Tsung Chang [Taïwan] ; Gregory T. Everson [États-Unis] ; Jeong Heo [Corée du Sud] ; Guido Gerken [Allemagne] ; Boris Yoffe [États-Unis] ; William J. Towner [États-Unis] ; Marc Bourliere [France] ; Sophie Metivier [France] ; Chi-Jen Chu [Taïwan] ; William Sievert [Australie] ; Jean-Pierre Bronowicki [France] ; Dominique Thabut [France] ; Youn-Jae Lee [Corée du Sud] ; Jia-Horng Kao [Taïwan] ; Fiona Mcphee [États-Unis] ; Justin Kopit [États-Unis] ; Patricia Mendez [États-Unis] ; Misti Linaberry [États-Unis] ; Eric Hughes [États-Unis] ; Stephanie Noviello [États-Unis]Source :
- Lancet (London, England) [ 1474-547X ] ; 2014.
Descripteurs français
- KwdFr :
- ARN viral (sang), Administration par voie orale, Adulte, Adulte d'âge moyen, Antiviraux (administration et posologie), Antiviraux (usage thérapeutique), Association de médicaments, Femelle, Génotype, Hepacivirus (), Hepacivirus (génétique), Hepacivirus (isolement et purification), Humains, Hépatite C chronique (traitement médicamenteux), Hépatite C chronique (virologie), Imidazoles (administration et posologie), Imidazoles (usage thérapeutique), Isoquinoléines (administration et posologie), Isoquinoléines (usage thérapeutique), Jeune adulte, Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Sulfonamides (administration et posologie), Sulfonamides (usage thérapeutique).
- MESH :
- administration et posologie : Antiviraux, Imidazoles, Isoquinoléines, Sulfonamides.
- génétique : Hepacivirus.
- isolement et purification : Hepacivirus.
- sang : ARN viral.
- traitement médicamenteux : Hépatite C chronique.
- usage thérapeutique : Antiviraux, Imidazoles, Isoquinoléines, Sulfonamides.
- virologie : Hépatite C chronique.
- Administration par voie orale, Adulte, Adulte d'âge moyen, Association de médicaments, Femelle, Génotype, Hepacivirus, Humains, Jeune adulte, Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Administration, Oral, Adult, Aged, Aged, 80 and over, Antiviral Agents (administration & dosage), Antiviral Agents (therapeutic use), Drug Therapy, Combination, Female, Genotype, Hepacivirus (classification), Hepacivirus (genetics), Hepacivirus (isolation & purification), Hepatitis C, Chronic (drug therapy), Hepatitis C, Chronic (virology), Humans, Imidazoles (administration & dosage), Imidazoles (therapeutic use), Isoquinolines (administration & dosage), Isoquinolines (therapeutic use), Male, Middle Aged, RNA, Viral (blood), Sulfonamides (administration & dosage), Sulfonamides (therapeutic use), Treatment Outcome, Young Adult.
- MESH :
- chemical , administration & dosage : Antiviral Agents, Imidazoles, Isoquinolines, Sulfonamides.
- chemical , blood : RNA, Viral.
- chemical , therapeutic use : Antiviral Agents, Imidazoles, Isoquinolines, Sulfonamides.
- classification : Hepacivirus.
- drug therapy : Hepatitis C, Chronic.
- genetics : Hepacivirus.
- isolation & purification : Hepacivirus.
- virology : Hepatitis C, Chronic.
- Administration, Oral, Adult, Aged, Aged, 80 and over, Drug Therapy, Combination, Female, Genotype, Humans, Male, Middle Aged, Treatment Outcome, Young Adult.
Abstract
An unmet need exists for interferon-free and ribavirin-free treatments for chronic hepatitis C virus (HCV) infection. In this study, we assessed all-oral therapy with daclatasvir (NS5A replication complex inhibitor) plus asunaprevir (NS3 protease inhibitor) in patients with genotype 1b infection, including those with high unmet needs or cirrhosis, or both.
DOI: 10.1016/S0140-6736(14)61059-X
PubMed: 25078304
Affiliations:
- Allemagne, Australie, Corée du Sud, France, Taïwan, États-Unis
- Californie, Colorado, Connecticut, Grand Est, Lorraine (région), Michigan, Midi-Pyrénées, New Jersey, Occitanie (région administrative), Provence-Alpes-Côte d'Azur, Texas, État de New York, Île-de-France
- Marseille, Nancy, Paris, Toulouse, Vandœuvre-lès-Nancy
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003357
- to stream PubMed, to step Curation: 003246
- to stream PubMed, to step Checkpoint: 003246
- to stream Ncbi, to step Merge: 001C75
- to stream Ncbi, to step Curation: 001C75
- to stream Ncbi, to step Checkpoint: 001C75
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- to stream Main, to step Curation: 003C23
Le document en format XML
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Towner</name><affiliation wicri:level="2"><nlm:affiliation>Kaiser Permanente, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kaiser Permanente, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourliere">Marc Bourliere</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint Joseph, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint Joseph, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Metivier, Sophie" sort="Metivier, Sophie" uniqKey="Metivier S" first="Sophie" last="Metivier">Sophie Metivier</name><affiliation wicri:level="3"><nlm:affiliation>CHU Purpan, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Chu, Chi Jen" sort="Chu, Chi Jen" uniqKey="Chu C" first="Chi-Jen" last="Chu">Chi-Jen Chu</name><affiliation wicri:level="1"><nlm:affiliation>Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei Veterans General Hospital and National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Sievert, William" sort="Sievert, William" uniqKey="Sievert W" first="William" last="Sievert">William Sievert</name><affiliation wicri:level="1"><nlm:affiliation>Monash Health and Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Health and Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Bronowicki, Jean Pierre" sort="Bronowicki, Jean Pierre" uniqKey="Bronowicki J" first="Jean-Pierre" last="Bronowicki">Jean-Pierre Bronowicki</name><affiliation wicri:level="3"><nlm:affiliation>INSERM Unité 954, Centre Hospitalier Universitaire de Nancy and Université de Lorraine, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 954, Centre Hospitalier Universitaire de Nancy and Université de Lorraine, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine 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Sud</country><wicri:regionArea>Inje University Busan Paik Hospital, Busan</wicri:regionArea><wicri:noRegion>Busan</wicri:noRegion></affiliation></author><author><name sortKey="Kao, Jia Horng" sort="Kao, Jia Horng" uniqKey="Kao J" first="Jia-Horng" last="Kao">Jia-Horng Kao</name><affiliation wicri:level="1"><nlm:affiliation>National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Wallingford, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Wallingford, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Kopit, Justin" sort="Kopit, Justin" uniqKey="Kopit J" first="Justin" last="Kopit">Justin Kopit</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Wallingford, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Wallingford, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Mendez, Patricia" sort="Mendez, Patricia" uniqKey="Mendez P" first="Patricia" last="Mendez">Patricia Mendez</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Linaberry, Misti" sort="Linaberry, Misti" uniqKey="Linaberry M" first="Misti" last="Linaberry">Misti Linaberry</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Hughes, Eric" sort="Hughes, Eric" uniqKey="Hughes E" first="Eric" last="Hughes">Eric Hughes</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Noviello, Stephanie" sort="Noviello, Stephanie" uniqKey="Noviello S" first="Stephanie" last="Noviello">Stephanie Noviello</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25078304</idno><idno type="pmid">25078304</idno><idno type="doi">10.1016/S0140-6736(14)61059-X</idno><idno type="wicri:Area/PubMed/Corpus">003357</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003357</idno><idno type="wicri:Area/PubMed/Curation">003246</idno><idno 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Hannover-Braunschweig, Germany. Electronic address: manns.michael@mh-hannover.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), Hannover-Braunschweig</wicri:regionArea><wicri:noRegion>Hannover-Braunschweig</wicri:noRegion><wicri:noRegion>Hannover-Braunschweig</wicri:noRegion><wicri:noRegion>Hannover-Braunschweig</wicri:noRegion></affiliation></author><author><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Weill Cornell Medical College, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Weill Cornell Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Beaujon, Clichy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Beaujon, Clichy</wicri:regionArea><wicri:noRegion>Clichy</wicri:noRegion><wicri:noRegion>Clichy</wicri:noRegion></affiliation></author><author><name sortKey="Gordon, Stuart C" sort="Gordon, Stuart C" uniqKey="Gordon S" first="Stuart C" last="Gordon">Stuart C. Gordon</name><affiliation wicri:level="2"><nlm:affiliation>Henry Ford Health Systems, Detroit, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Henry Ford Health Systems, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Peng, Cheng Yuan" sort="Peng, Cheng Yuan" uniqKey="Peng C" first="Cheng-Yuan" last="Peng">Cheng-Yuan Peng</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Ting Tsung" sort="Chang, Ting Tsung" uniqKey="Chang T" first="Ting-Tsung" last="Chang">Ting-Tsung Chang</name><affiliation wicri:level="1"><nlm:affiliation>National Cheng Kung University Hospital, Tainan, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Cheng Kung University Hospital, Tainan</wicri:regionArea><wicri:noRegion>Tainan</wicri:noRegion></affiliation></author><author><name sortKey="Everson, Gregory T" sort="Everson, Gregory T" uniqKey="Everson G" first="Gregory T" last="Everson">Gregory T. Everson</name><affiliation wicri:level="2"><nlm:affiliation>University of Colorado Denver, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Colorado Denver, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Heo, Jeong" sort="Heo, Jeong" uniqKey="Heo J" first="Jeong" last="Heo">Jeong Heo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, College of Medicine, Pusan National University and Medical Research Institute, Pusan National University Hospital, Busan, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, College of Medicine, Pusan National University and Medical Research Institute, Pusan National University Hospital, Busan</wicri:regionArea><wicri:noRegion>Busan</wicri:noRegion></affiliation></author><author><name sortKey="Gerken, Guido" sort="Gerken, Guido" uniqKey="Gerken G" first="Guido" last="Gerken">Guido Gerken</name><affiliation wicri:level="1"><nlm:affiliation>University of Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Yoffe, Boris" sort="Yoffe, Boris" uniqKey="Yoffe B" first="Boris" last="Yoffe">Boris Yoffe</name><affiliation wicri:level="2"><nlm:affiliation>VAMC, Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>VAMC, Baylor College of Medicine, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Towner, William J" sort="Towner, William J" uniqKey="Towner W" first="William J" last="Towner">William J. Towner</name><affiliation wicri:level="2"><nlm:affiliation>Kaiser Permanente, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kaiser Permanente, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourliere">Marc Bourliere</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint Joseph, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint Joseph, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Metivier, Sophie" sort="Metivier, Sophie" uniqKey="Metivier S" first="Sophie" last="Metivier">Sophie Metivier</name><affiliation wicri:level="3"><nlm:affiliation>CHU Purpan, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Chu, Chi Jen" sort="Chu, Chi Jen" uniqKey="Chu C" first="Chi-Jen" last="Chu">Chi-Jen Chu</name><affiliation wicri:level="1"><nlm:affiliation>Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei Veterans General Hospital and National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Sievert, William" sort="Sievert, William" uniqKey="Sievert W" first="William" last="Sievert">William Sievert</name><affiliation wicri:level="1"><nlm:affiliation>Monash Health and Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Health and Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Bronowicki, Jean Pierre" sort="Bronowicki, Jean Pierre" uniqKey="Bronowicki J" first="Jean-Pierre" last="Bronowicki">Jean-Pierre Bronowicki</name><affiliation wicri:level="3"><nlm:affiliation>INSERM Unité 954, Centre Hospitalier Universitaire de Nancy and Université de Lorraine, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 954, Centre Hospitalier Universitaire de Nancy and Université de Lorraine, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Thabut, Dominique" sort="Thabut, Dominique" uniqKey="Thabut D" first="Dominique" last="Thabut">Dominique Thabut</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lee, Youn Jae" sort="Lee, Youn Jae" uniqKey="Lee Y" first="Youn-Jae" last="Lee">Youn-Jae Lee</name><affiliation wicri:level="1"><nlm:affiliation>Inje University Busan Paik Hospital, Busan, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Inje University Busan Paik Hospital, Busan</wicri:regionArea><wicri:noRegion>Busan</wicri:noRegion></affiliation></author><author><name sortKey="Kao, Jia Horng" sort="Kao, Jia Horng" uniqKey="Kao J" first="Jia-Horng" last="Kao">Jia-Horng Kao</name><affiliation wicri:level="1"><nlm:affiliation>National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Wallingford, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Wallingford, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Kopit, Justin" sort="Kopit, Justin" uniqKey="Kopit J" first="Justin" last="Kopit">Justin Kopit</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Wallingford, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Wallingford, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Mendez, Patricia" sort="Mendez, Patricia" uniqKey="Mendez P" first="Patricia" last="Mendez">Patricia Mendez</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Linaberry, Misti" sort="Linaberry, Misti" uniqKey="Linaberry M" first="Misti" last="Linaberry">Misti Linaberry</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Hughes, Eric" sort="Hughes, Eric" uniqKey="Hughes E" first="Eric" last="Hughes">Eric Hughes</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Noviello, Stephanie" sort="Noviello, Stephanie" uniqKey="Noviello S" first="Stephanie" last="Noviello">Stephanie Noviello</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiviral Agents (administration & dosage)</term><term>Antiviral Agents (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Female</term><term>Genotype</term><term>Hepacivirus (classification)</term><term>Hepacivirus (genetics)</term><term>Hepacivirus (isolation & purification)</term><term>Hepatitis C, Chronic (drug therapy)</term><term>Hepatitis C, Chronic (virology)</term><term>Humans</term><term>Imidazoles (administration & dosage)</term><term>Imidazoles (therapeutic use)</term><term>Isoquinolines (administration & dosage)</term><term>Isoquinolines (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>RNA, Viral (blood)</term><term>Sulfonamides (administration & dosage)</term><term>Sulfonamides (therapeutic use)</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (sang)</term><term>Administration par voie orale</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antiviraux (administration et posologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Association de médicaments</term><term>Femelle</term><term>Génotype</term><term>Hepacivirus ()</term><term>Hepacivirus (génétique)</term><term>Hepacivirus (isolement et purification)</term><term>Humains</term><term>Hépatite C chronique (traitement médicamenteux)</term><term>Hépatite C chronique (virologie)</term><term>Imidazoles (administration et posologie)</term><term>Imidazoles (usage thérapeutique)</term><term>Isoquinoléines (administration et posologie)</term><term>Isoquinoléines (usage thérapeutique)</term><term>Jeune adulte</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Sulfonamides (administration et posologie)</term><term>Sulfonamides (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Imidazoles</term><term>Isoquinolines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Imidazoles</term><term>Isoquinolines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term><term>Imidazoles</term><term>Isoquinoléines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite C chronique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Imidazoles</term><term>Isoquinoléines</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite C chronique</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Drug Therapy, Combination</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Femelle</term><term>Génotype</term><term>Hepacivirus</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An unmet need exists for interferon-free and ribavirin-free treatments for chronic hepatitis C virus (HCV) infection. In this study, we assessed all-oral therapy with daclatasvir (NS5A replication complex inhibitor) plus asunaprevir (NS3 protease inhibitor) in patients with genotype 1b infection, including those with high unmet needs or cirrhosis, or both.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Corée du Sud</li><li>France</li><li>Taïwan</li><li>États-Unis</li></country><region><li>Californie</li><li>Colorado</li><li>Connecticut</li><li>Grand Est</li><li>Lorraine (région)</li><li>Michigan</li><li>Midi-Pyrénées</li><li>New Jersey</li><li>Occitanie (région administrative)</li><li>Provence-Alpes-Côte d'Azur</li><li>Texas</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Marseille</li><li>Nancy</li><li>Paris</li><li>Toulouse</li><li>Vandœuvre-lès-Nancy</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Manns, Michael" sort="Manns, Michael" uniqKey="Manns M" first="Michael" last="Manns">Michael Manns</name></noRegion><name sortKey="Gerken, Guido" sort="Gerken, Guido" uniqKey="Gerken G" first="Guido" last="Gerken">Guido Gerken</name></country><country name="France"><region name="Île-de-France"><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name></region><name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourliere">Marc Bourliere</name><name sortKey="Bronowicki, Jean Pierre" sort="Bronowicki, Jean Pierre" uniqKey="Bronowicki J" first="Jean-Pierre" last="Bronowicki">Jean-Pierre Bronowicki</name><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name><name sortKey="Metivier, Sophie" sort="Metivier, Sophie" uniqKey="Metivier S" first="Sophie" last="Metivier">Sophie Metivier</name><name sortKey="Thabut, Dominique" sort="Thabut, Dominique" uniqKey="Thabut D" first="Dominique" last="Thabut">Dominique Thabut</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name></region><name sortKey="Everson, Gregory T" sort="Everson, Gregory T" uniqKey="Everson G" first="Gregory T" last="Everson">Gregory T. Everson</name><name sortKey="Gordon, Stuart C" sort="Gordon, Stuart C" uniqKey="Gordon S" first="Stuart C" last="Gordon">Stuart C. Gordon</name><name sortKey="Hughes, Eric" sort="Hughes, Eric" uniqKey="Hughes E" first="Eric" last="Hughes">Eric Hughes</name><name sortKey="Kopit, Justin" sort="Kopit, Justin" uniqKey="Kopit J" first="Justin" last="Kopit">Justin Kopit</name><name sortKey="Linaberry, Misti" sort="Linaberry, Misti" uniqKey="Linaberry M" first="Misti" last="Linaberry">Misti Linaberry</name><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><name sortKey="Mendez, Patricia" sort="Mendez, Patricia" uniqKey="Mendez P" first="Patricia" last="Mendez">Patricia Mendez</name><name sortKey="Noviello, Stephanie" sort="Noviello, Stephanie" uniqKey="Noviello S" first="Stephanie" last="Noviello">Stephanie Noviello</name><name sortKey="Towner, William J" sort="Towner, William J" uniqKey="Towner W" first="William J" last="Towner">William J. Towner</name><name sortKey="Yoffe, Boris" sort="Yoffe, Boris" uniqKey="Yoffe B" first="Boris" last="Yoffe">Boris Yoffe</name></country><country name="Taïwan"><noRegion><name sortKey="Peng, Cheng Yuan" sort="Peng, Cheng Yuan" uniqKey="Peng C" first="Cheng-Yuan" last="Peng">Cheng-Yuan Peng</name></noRegion><name sortKey="Chang, Ting Tsung" sort="Chang, Ting Tsung" uniqKey="Chang T" first="Ting-Tsung" last="Chang">Ting-Tsung Chang</name><name sortKey="Chu, Chi Jen" sort="Chu, Chi Jen" uniqKey="Chu C" first="Chi-Jen" last="Chu">Chi-Jen Chu</name><name sortKey="Kao, Jia Horng" sort="Kao, Jia Horng" uniqKey="Kao J" first="Jia-Horng" last="Kao">Jia-Horng Kao</name></country><country name="Corée du Sud"><noRegion><name sortKey="Heo, Jeong" sort="Heo, Jeong" uniqKey="Heo J" first="Jeong" last="Heo">Jeong Heo</name></noRegion><name sortKey="Lee, Youn Jae" sort="Lee, Youn Jae" uniqKey="Lee Y" first="Youn-Jae" last="Lee">Youn-Jae Lee</name></country><country name="Australie"><noRegion><name sortKey="Sievert, William" sort="Sievert, William" uniqKey="Sievert W" first="William" last="Sievert">William Sievert</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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